/TECHNOLOGY
ProgramMable Gene insertion
THE Gene Weaver Technology Platform is a naturally derived programmable tool for controlled cutting and precision insertion of large genetic payloads.
Genetic medicines are driving a revolution in therapeutics.
The enhanced gene editing/modification capability of the Gene Weaver Technology Platform is set to address the challenges facing the first generation of editing tools used to create the current genetic medicine pipelines across the industry. Current limitations include:
Off-target effects
(something about difficulty of insertion of cargo/large cargos)
Cell cycle restricted
All of which limit the scope and applicability of these transformative therapeutics.
uniquely programmable enzymatic system for controlled cutting and precision insertion of large payloads
Our technology advances next level controlled genetic cargo integration because of its:
Specificity.
Using a large recognition region drives precise placement.
Broad cell applicability
Not just cycling cells. Non-reliance on cell homology-directed repair (HR) processes offers potential for post-mitotic cells.
Programmability.
Defined engineerable recognition elements within the system allow most, if not all, targets to be tractable.
Precision outcome
Removes reliance on 'traditional' double stranded breaks (DSBs) and hopeful homology-directed repair (HR) approach.
Cargo size.
System supports a natural capacity of up to several kilobase.
This pioneering next generation technology is set to supersede currently available gene editing and insertion tools used to create the current genetic medicine pipelines across the industry.
Gene Weaver Technology Platform has the potential to make new genetic-based therapeutic modalities more durable and affordable.
Applications. Rewriting how genes are delivered and expressed: from discovery to therapy.
Regenerative Medicine: Controlled Cell Reprogramming.
Reprogramming somatic cells into induced pluripotent or lineage-specific cells.
Gene Weaver’s gene therapy platform will enable insertion and continuous expression of genes without damaging the genome. This allows safer, scalable generation of therapeutic cell types, such as cardiomyocytes, neurons, or pancreatic β-cells. Gene Weaver is accelerating regenerative therapies for degenerative diseases and organ repair.
Genetic Medicine: Programmable Gene Editing and Regulation
Precise manipulation of DNA and RNA to modify gene function and repair pathogenic mutations.
By supporting large and complex genetic constructs and maintaining high editing efficiency in traditionally hard-to-engineer cells (including primary immune and stem cells), Gene Weaver expands the design space for next-generation gene and cell therapies. This approach offers improved safety and a broader applicability across therapeutic modalities.
Functional Genomics: Expanded Genetic Design Space
High-throughput, programmable gene modulation beyond simple knockouts for sustained regulatory control.
Gene Weaver supports complex genetic constructs and sustained regulatory control. This unlocks functional genomics studies that were previously impractical; such as combinatorial perturbations, long-term expression tuning, and multi-gene pathway interrogation; and dramatically improves target discovery fidelity and translational relevance.
We’d love to hear from you.
Whether you’re interested in learning more about our programmable gene integration technology, exploring collaboration opportunities, or just want to connect with the team, we’d be delighted to have a conversation. Fill out the form here and a member of the Gene Weaver team will get back to you as soon as possible.
